Transfection

Research reveals the assembly dynamics of nucleocapsid protein condensates can be regulated by small molecules with therapeutic potential

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In a recent study posted to bioRxiv*, researchers developed a screening platform and identified molecules with anti-coronavirus (anti-CoV) activity. Study: A screen for modulation of nucleocapsid protein condensation identifies small molecules with anti-coronavirus activity. Image Credit: jijomathaidesigners/Shutterstock Background Biomolecular condensates are membrane-less organelles formed by liquid-liquid phase separation of proteins or ribonucleic acids (RNAs). The … Read more

The biological properties of the SARS-CoV-2 E protein in the context of HIV-1

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In a recent study published in Retrovirologyresearchers assessed the effectiveness of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 envelope (E) proteins against human immunodeficiency virus (HIV)-1. Study: The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1). Image Credit: Corona Borealis Studio/Shutterstock Background Viroporins are ion … Read more

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

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In a recent study posted to the bioRxiv* preprint server, researchers presented a functional analysis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 3c (ORF3c) protein. Study: The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity. Image Credit: Corona Borealis Studio/Shutterstock Background The genome of SARS-CoV-2 encodes a wide … Read more

emerging technologies are capable of unlocking the promise of biologically targeted mRNA therapeutics

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In a recent article published in Nature Biotechnologyresearchers reviewed technology advancements that will unlock the promise of biologically targeted messenger ribonucleic acid (mRNA) therapeutics beyond vaccines. Study: Unlocking the promise of mRNA therapeutics. Image Credit: nobeastsofierce/Shutterstock Background The first part of the review focused on the design and purification of the mRNA cargos, including novel … Read more