SARS-CoV-2 structural proteins trigger periodontal fibrosis

In a recent study posted to the bioRxiv* preprint server, researchers examined the pathological impacts of the structural components of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on human periodontal cells and tissue to understand the association between coronavirus disease 2019 (COVID-19) and deteriorating oral health. Study: SARS-CoV-2 causes periodontal fibrosis by deregulating mitochondrial β-oxidation. … Read more

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

In a recent study posted to bioRxiv*, researchers developed a measles virus (MeV)-vectored vaccine capable of inducing high neutralizing antibody (nAb) responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants. Image Credit: Kateryna … Read more

What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of ceramide (CER) and cholesterol (CHOL) on membrane fusion mediated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Study: Cholesterol and ceramide facilitate SARS-CoV-2 Spike protein-mediated membrane fusion. Image Credit: CROCOTHERY/Shutterstock. Background SARS-CoV-2 entrance into host cells is … Read more

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

In a recent study posted to the bioRxiv* server, researchers mutated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein’s trimeric structure to design a novel prefusion S antigen, S2D14. Study: Structural and Computational Design of a SARS-2 Spike Antigen with Increased Receptor Binding Domain Exposure and Improved Immunogenicity. Image Credit: creativeneko/Shutterstock Background … Read more

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers used cellular cryo-electron tomography (cryo-ET) to demonstrate the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in coronavirus disease 2019 (COVID-19)-triggered severe coagulopathies. Study: Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein. Image Credit: Sergejs Pintis/Shutterstock Background … Read more

How COVID-19 Spike Protein Accumulation Could Result in Thromboembolism

Beloved weatherman Al Roker, who transformed his life with bariatric surgery years ago and showed America how weight loss could be permanent, has always been honest about his health on television. In January 2021 he was so excited to get vaccinated for COVID-19 that he clicked the enter button over and over to get his … Read more

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery until now. Researchers of the University of Bristol-led study, published in Science advances today [23 November], say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses-; from the 2002 SARS-CoV outbreak … Read more

Research reveals existence of a hidden ”pocket” on the surface of key SARS-CoV-2 protein

With the continuous emergence of new variants and the risk of new strains of the virus, the development of innovative therapies against SARS-CoV-2 remains a major public health challenge. Currently, the proteins that are on the surface of the virus and/or are involved in its replication are the preferred therapeutic targets, such as the spike … Read more

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

In a recent study posted to the bioRxiv* preprint server, a team of researchers investigated the change in the stability, antigenicity, and protein expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein. Study: Enhanced stability of the … Read more

Mosaic nanoparticles displaying spike protein trimers from different coronaviruses elicits cross-reactive protection

In a recent study under review at the Nature Portfolio journal and currently posted to Research Square* preprint server, researchers developed and assessed the immunogenicity of nanoparticles expressing spike trimers from coronaviruses (CoVs). CoVs, particularly beta-CoVs, thrive in animal reservoirs and constantly threaten human health. Seven CoVs infect humans, including severe acute respiratory syndrome coronavirus … Read more