Researchers discover novel drug candidate targets for advanced non-alcoholic fatty liver disease

Using the latest technologies-including both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize key scar-producing liver cells-researchers have uncovered novel candidate drug targets for non-alcoholic fatty liver disease ( NAFLD). The research was led by investigators at the Icahn School of Medicine at Mount Sinai. Utilizing … Read more

Salk scientists show how a microprotein can increase appetite in mice

Obesity and metabolic diseases, such as diabetes, are extremely common in the United States. Tiny proteins called microproteins have long been overlooked in research, but new evidence demonstrates that they have an important role in metabolism. Salk scientists have discovered that both brown and white fat is filled with thousands of previously unknown microproteins, and … Read more

How to eat healthy: The Paleo diet may provide weight loss benefits, but its long-term effects are unknown

For people who are looking to lose weight quickly, the Paleo diet – which is based on the food that people ate during the Paleolithic Era – may provide the short-term benefits they are looking for. But some scientists caution that its long-term effects are not well studied. During the Paleolithic Era, which occurred 2.5 … Read more

Researchers discover a protein linked with the onset of anthracycline-associated cardiac toxicity

Anthracyclines are a class of chemotherapies effective in treating many forms of cancer, including leukemias, lymphomas and breast cancer. Anthracyclines -; such as doxorubicin, frequently used against breast cancer -; kill cancer cells by damaging their DNA. However, these effective chemotherapies also cause toxic heart effects in about ten percent of patients that can eventually … Read more

Scientists have discovered a key antibody that could yield new treatments against Strep A

Researchers have discovered an antibody in recovered Strep A patients that could protect against an infection of the potentially dangerous bacteria. The team at Lund University in Sweden found that this antibody has a rare way of binding to its target protein, which they say could explain why so many attempts to develop a Strep … Read more

How to eat healthy: The Paleo diet may provide weight loss benefits, but its long-term effects are unknown

For people who are looking to lose weight quickly, the Paleo diet – which is based on the food that people ate during the Paleolithic Era – may provide the short-term benefits they are looking for. But some scientists caution that its long-term effects are not well studied. During the Paleolithic Era, which occurred 2.5 … Read more

Meta-analysis shows dose-response between protein intake and muscle strength

Writing in Sports Medicine – Open, ​the researcher from Meiji and Waseda University added that protein intake must be coupled with resistance training to see a significant improvement in muscle strength. ​ This is said to be the first time that a dose-response was found between protein intake and muscle strength. “​Previous studies have clarified … Read more

Fatty liver disease adversely affects brain health: a study

ANI | Updated: Dec 25, 2022 04:12 ist London [UK]December 25 (ANI): Scientists at the Roger Williams Institute of Hepatology, affiliated with King’s College London and the University of Lausanne, discovered in a study examining the link between non-alcoholic fatty liver disease (NAFLD) and brain dysfunction that an accumulation of fat in the liver causes … Read more

UC San Diego researchers rewrite the textbook on gene regulation

A fundamental principle of molecular biology governs how proteins are made within the cell, which happens in two stages called transcription and translation. During transcription, information stored in DNA is copied into messenger RNA (mRNA). Then during translation, the ribosomes assemble proteins of one amino acid at a time based on the instruction specified on … Read more

Basecamp Research raises $20M to map life on earth and design proteins to match

Less than one percent of the biochemistries in nature have been discovered – a fraction of that percentage has been fully characterized in the real world.​,” said Oliver Vince, co-founder at Basecamp Research. “Recent advances in bioinformatics, AI and data science are enabling our team to map a world of untapped possibility, and we’re just … Read more