Protein Expression

Protein expression signature distinguishes early from late stage diffuse alveolar damage

by

In a recent study posted to medRxiv* preprint server, researchers identified a protein expression signature that can distinguish early diffuse alveolar damage (DAD) from late DAD in coronavirus disease 2019 (COVID-19) patients. Study: Identification of a protein expression signature distinguishing early from organizing diffuse alveolar damage in COVID-19 patients. Image Credit: CROCOTHERY/Shutterstock Background To date, … Read more

Global Protein Expression, Purification and Isolation

by

Visiongain has published a new report entitled Protein Expression, Purification and Isolation Technology 2022-2032. It includes profiles of Protein Expression, Purification and Isolation Technology and Forecasts Market Segment by Technology (Protein Expression Technology). [Cell-Free Expression, Bacterial Expression, Yeast Expression, Algal Expression, Insect Expression, Others]Protein Purification & Isolation Technology [Ultrafiltration, Precipitation, Chromatography, Electrophoresis, Western Blotting, Others), … Read more

Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

by

In a recent study posted to the bioRxiv* server, researchers evaluated blood plasma proteins to identify new targets for coronavirus disease 2019 (COVID-19) treatment approaches and prevent complications associated with severe illness. Study: Proteomic profiling identifies biomarkers of COVID-19 severity. Image Credit: Billion Photos/Shutterstock Background There is an unmet need for effective therapies for severe … Read more

Novel mRNA vaccines encoding monkeypox virus proteins show promise in preclinical studies

by

In a recent study posted to the bioRxiv* preprint server, researchers in China demonstrated the efficacy of three messenger ribonucleic acid (mRNA) technology-based Monkeypox virus (MPXV) vaccines in combating a lethal Vaccinia virus (VACV) challenge in mice models. Study: Novel mRNA vaccines encoding monkeypox virus M1R and A35R protect mice from a lethal virus challenge. … Read more

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

by

In a recent study posted to the bioRxiv* preprint server, researchers presented a functional analysis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 3c (ORF3c) protein. Study: The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity. Image Credit: Corona Borealis Studio/Shutterstock Background The genome of SARS-CoV-2 encodes a wide … Read more

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

by

In a recent study posted to the bioRxiv* preprint server, a team of researchers investigated the change in the stability, antigenicity, and protein expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein. Study: Enhanced stability of the … Read more

emerging technologies are capable of unlocking the promise of biologically targeted mRNA therapeutics

by

In a recent article published in Nature Biotechnologyresearchers reviewed technology advancements that will unlock the promise of biologically targeted messenger ribonucleic acid (mRNA) therapeutics beyond vaccines. Study: Unlocking the promise of mRNA therapeutics. Image Credit: nobeastsofierce/Shutterstock Background The first part of the review focused on the design and purification of the mRNA cargos, including novel … Read more