Preclinical

Novel mRNA vaccines encoding monkeypox virus proteins show promise in preclinical studies

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In a recent study posted to the bioRxiv* preprint server, researchers in China demonstrated the efficacy of three messenger ribonucleic acid (mRNA) technology-based Monkeypox virus (MPXV) vaccines in combating a lethal Vaccinia virus (VACV) challenge in mice models. Study: Novel mRNA vaccines encoding monkeypox virus M1R and A35R protect mice from a lethal virus challenge. … Read more

emerging technologies are capable of unlocking the promise of biologically targeted mRNA therapeutics

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In a recent article published in Nature Biotechnologyresearchers reviewed technology advancements that will unlock the promise of biologically targeted messenger ribonucleic acid (mRNA) therapeutics beyond vaccines. Study: Unlocking the promise of mRNA therapeutics. Image Credit: nobeastsofierce/Shutterstock Background The first part of the review focused on the design and purification of the mRNA cargos, including novel … Read more