Phosphorylation

SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

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In a recent study published in the journal PLOS pathogensresearchers investigated the mechanisms through which the human common cold Betacoronavirus OC43 (HCoV-OC43) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit the formation of stress granules. Study: Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. Image Credit: MIA Studio/Shutterstock Background Stress … Read more

Research reveals the assembly dynamics of nucleocapsid protein condensates can be regulated by small molecules with therapeutic potential

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In a recent study posted to bioRxiv*, researchers developed a screening platform and identified molecules with anti-coronavirus (anti-CoV) activity. Study: A screen for modulation of nucleocapsid protein condensation identifies small molecules with anti-coronavirus activity. Image Credit: jijomathaidesigners/Shutterstock Background Biomolecular condensates are membrane-less organelles formed by liquid-liquid phase separation of proteins or ribonucleic acids (RNAs). The … Read more

New chemical probe can selectively inhibit human COQ8A protein in cells

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Inhibition of the COQ8 protein could be beneficial in the treatment of diseases such as cancer. CoQ8 is needed for the biosynthesis of coenzyme Q, also known as ubiquinone. A new collaborative study from the University of Eastern Finland, Washington University in St. Louis, University of Wisconsin-Madison, University of North Carolina at Chapel Hill and … Read more