Scientists explore synthesis of griffithsin in cell-free systems

A recent study posted to the bioRxiv* preprint server described the cell-free manufacturing of griffithsin (GRFT), a broad-spectrum antiviral protein. Study: An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics. Image Credit: Juan Gaertner/Shutterstock Drugs and vaccines are currently manufactured in large and expensive facilities. The drug … Read more

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

In a recent study posted to bioRxiv*, researchers developed a measles virus (MeV)-vectored vaccine capable of inducing high neutralizing antibody (nAb) responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants. Image Credit: Kateryna … Read more

Protein expression signature distinguishes early from late stage diffuse alveolar damage

In a recent study posted to medRxiv* preprint server, researchers identified a protein expression signature that can distinguish early diffuse alveolar damage (DAD) from late DAD in coronavirus disease 2019 (COVID-19) patients. Study: Identification of a protein expression signature distinguishing early from organizing diffuse alveolar damage in COVID-19 patients. Image Credit: CROCOTHERY/Shutterstock Background To date, … Read more

Study shows how dietary saturated/trans fats promote liver tumorigenesis

Fatty foods harm our health. Prior research has established a link between the consumption of dietary fats and non-alcoholic fatty liver disease, which subsequently leads to inflammation and tumor formation in the liver. However, the precise effects of dietary fat composition on liver tumorigenesis remain elusive. A new study shows that dietary saturated/trans fats, but … Read more

Exploring a variant-adapted SARS-CoV-2 recombinant protein vaccine

In a recent study posted to the medRxiv* preprint server, researchers assessed the immunogenicity of a variant-adapted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recombinant protein vaccine boosted with an AS03 adjuvant. Study: Safety and immunogenicity of a variant-adapted SARS-CoV-2 recombinant protein vaccine with AS03 adjuvant as a booster in adults primed with authorized vaccines. … Read more

COVID-19 amplifies damage to the central nervous system in Alzheimer’s disease

In a recent study published in the journal Annals of Diagnostic Pathologyresearchers Alzheimer in the United States evaluated the impact of coronavirus disease 2019 (COVID-19) on central nervous system (CNS) damage in’s disease (AD). Studies have reported that the human brain is highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated pathological changes. In … Read more

Exercising in the afternoon or at night best for blood sugar control

A new Diabetology journal study discusses the associations of breaks in sedentary time and timing of physical activity with insulin resistance and liver fat content among a middle-aged population. Study: Timing of physical activity in relation to liver fat content and insulin resistance. Image Credit: Studio Romantic / The health impacts of a sedentary … Read more

SpyCatcher-SpyTag technology used to develop recombinant protein-based intranasal vaccine against SARS-CoV-2

The findings of a new study posted to the bioRxiv* preprint server showed that the intranasal SpyCage vaccine platform can be protective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may prove to be a versatile and adaptable modality for the formulation of intranasal vaccines that target respiratory pathogens. Study: Intranasal virus-particle mimicking vaccine … Read more

Dyadic Receives Regulatory Approval to Initiate Phase 1

JUPITER, Fla., Oct. 27, 2022 (GLOBE NEWSWIRE) — Dyadic International, Inc. (“Dyadic”, “we”, “us”, “our”, or the “Company”) (NASDAQ: DYAI), a global biotechnology company focused on building innovative microbial platforms to address the growing demand for global protein production and unmet clinical needs for effective and affordable biopharmaceutical products for human and animal health, today … Read more

Motif-based SARS-CoV-2 protein-human protein interactions as potential antiviral target sites

In a recent study posted to the bioRxiv* preprint server, researchers performed a ProP-PD (proteomic peptide phage display) analysis to identify peptides from intrinsically disordered human (host) proteome regions that bind with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome-encoded folded protein domains (PDs). Study: Identification of motif-based interactions between SARS-CoV-2 protein domains and human … Read more