Landmark study challenges a 70-year-old theory of protein folding

Landmark study challenges a 70-year-old theory of protein folding

A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system . An illustration of a cellular … Read more

New chemical probe can selectively inhibit human COQ8A protein in cells

Inhibition of the COQ8 protein could be beneficial in the treatment of diseases such as cancer. CoQ8 is needed for the biosynthesis of coenzyme Q, also known as ubiquinone. A new collaborative study from the University of Eastern Finland, Washington University in St. Louis, University of Wisconsin-Madison, University of North Carolina at Chapel Hill and … Read more

Researchers discover a new function of CRISPR/Cas9 gene scissors

For several years now, the CRISPR/Cas9 gene scissors have been causing a sensation in science and medicine. This new tool of molecular biology has its origins in an ancient bacterial immune system. It protects bacteria from attack by so-called phages, ie viruses that infect bacteria. Researchers from the Institute of Structural Biology at the University … Read more

AI helps design synthetic DNA that controls cells’ protein production

With the help of an AI, researchers at Chalmers University of Technology, Sweden, have succeeded in designing synthetic DNA that controls the cells’ protein production. The technology can contribute to the development and production of vaccines, drugs for severe diseases, as well as alternative food proteins much faster and at significantly lower costs than today. … Read more

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery until now. Researchers of the University of Bristol-led study, published in Science advances today [23 November], say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses-; from the 2002 SARS-CoV outbreak … Read more