MERS-CoV

SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

by

In a recent study published in the journal PLOS pathogensresearchers investigated the mechanisms through which the human common cold Betacoronavirus OC43 (HCoV-OC43) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit the formation of stress granules. Study: Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. Image Credit: MIA Studio/Shutterstock Background Stress … Read more

SARS-CoV-1 and SARS-CoV-2 spike proteins utilize different mechanisms to bind to ACE2

by

A recent study published in the journal Frontiers in Molecular Biosciences applied computational approaches to study the binding mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV spike (S) proteins to the human angiotensin-converting enzyme 2 (ACE2) receptor. Study: Spike proteins of SARS-COV and SARS-COV-2 utilize different mechanisms to bind with human … Read more

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

by

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery until now. Researchers of the University of Bristol-led study, published in Science advances today [23 November], say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses-; from the 2002 SARS-CoV outbreak … Read more

The biological properties of the SARS-CoV-2 E protein in the context of HIV-1

by

In a recent study published in Retrovirologyresearchers assessed the effectiveness of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 envelope (E) proteins against human immunodeficiency virus (HIV)-1. Study: The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1). Image Credit: Corona Borealis Studio/Shutterstock Background Viroporins are ion … Read more

Mosaic nanoparticles displaying spike protein trimers from different coronaviruses elicits cross-reactive protection

by

In a recent study under review at the Nature Portfolio journal and currently posted to Research Square* preprint server, researchers developed and assessed the immunogenicity of nanoparticles expressing spike trimers from coronaviruses (CoVs). CoVs, particularly beta-CoVs, thrive in animal reservoirs and constantly threaten human health. Seven CoVs infect humans, including severe acute respiratory syndrome coronavirus … Read more