Researchers discover novel drug candidate targets for advanced non-alcoholic fatty liver disease

Using the latest technologies-including both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize key scar-producing liver cells-researchers have uncovered novel candidate drug targets for non-alcoholic fatty liver disease ( NAFLD). The research was led by investigators at the Icahn School of Medicine at Mount Sinai. Utilizing … Read more

What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

In a recent study posted to the bioRxiv* preprint server, researchers assessed the impact of ceramide (CER) and cholesterol (CHOL) on membrane fusion mediated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein. Study: Cholesterol and ceramide facilitate SARS-CoV-2 Spike protein-mediated membrane fusion. Image Credit: CROCOTHERY/Shutterstock. Background SARS-CoV-2 entrance into host cells is … Read more

emerging technologies are capable of unlocking the promise of biologically targeted mRNA therapeutics

In a recent article published in Nature Biotechnologyresearchers reviewed technology advancements that will unlock the promise of biologically targeted messenger ribonucleic acid (mRNA) therapeutics beyond vaccines. Study: Unlocking the promise of mRNA therapeutics. Image Credit: nobeastsofierce/Shutterstock Background The first part of the review focused on the design and purification of the mRNA cargos, including novel … Read more

Study sheds light on how Gram-negative bacteria construct outer membrane to resemble body armor

A new study published in the journal Science Advances sheds light on how Gram-negative bacteria like E. coli construct their outer membrane to resemble body armor, which has far-reaching implications for the development of antibiotics. Professor Colin Kleanthous in the Department of Biochemistry at the University of Oxford led the interdisciplinary study, with contributions from … Read more