Cryo-electron microscopy by University of Alabama at Birmingham researchers has exposed the structure of a bacterial virus with unprecedented detail. This is the first structure of a virus able to infect Staphylococcus epidermidis, and high-resolution knowledge of structure is a key link between viral biology and potential therapeutic use of the virus to quell bacterial … Read more
In a recent study posted to the bioRxiv* preprint server, researchers presented a functional analysis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 3c (ORF3c) protein. Study: The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity. Image Credit: Corona Borealis Studio/Shutterstock Background The genome of SARS-CoV-2 encodes a wide … Read more
Nov 15 2022 Lung cancer is the leading cause of cancer deaths globally and a top cause of cancer deaths in the Military Health System. However, the ability to determine which of these patients have aggressive tumors and which will respond better to certain treatments could soon be available through the collective analysis of proteins … Read more
Scientists at deCODE genetics in Iceland have discovered rare, protective loss-of-function variants that point to potential drug targets for nonalcoholic fatty liver disease (NAFLD). Scientists at deCODE genetics, a subsidiary of Amgen, publish today a large genome-wide association study on nonalcoholic fatty liver disease (NAFLD) in Nature Genetics. Sequence variants that associate with NAFLD were … Read more
In a recent study posted to the bioRxiv* preprint server, researchers performed a ProP-PD (proteomic peptide phage display) analysis to identify peptides from intrinsically disordered human (host) proteome regions that bind with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) genome-encoded folded protein domains (PDs). Study: Identification of motif-based interactions between SARS-CoV-2 protein domains and human … Read more