Efficacy

Scientists explore synthesis of griffithsin in cell-free systems

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A recent study posted to the bioRxiv* preprint server described the cell-free manufacturing of griffithsin (GRFT), a broad-spectrum antiviral protein. Study: An approach to rapid distributed manufacturing of broad spectrum anti-viral griffithsin using cell-free systems to mitigate pandemics. Image Credit: Juan Gaertner/Shutterstock Drugs and vaccines are currently manufactured in large and expensive facilities. The drug … Read more

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

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In a recent study posted to bioRxiv*, researchers developed a measles virus (MeV)-vectored vaccine capable of inducing high neutralizing antibody (nAb) responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants. Image Credit: Kateryna … Read more

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

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In a recent study posted to the bioRxiv* server, researchers mutated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein’s trimeric structure to design a novel prefusion S antigen, S2D14. Study: Structural and Computational Design of a SARS-2 Spike Antigen with Increased Receptor Binding Domain Exposure and Improved Immunogenicity. Image Credit: creativeneko/Shutterstock Background … Read more

Novel mRNA vaccines encoding monkeypox virus proteins show promise in preclinical studies

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In a recent study posted to the bioRxiv* preprint server, researchers in China demonstrated the efficacy of three messenger ribonucleic acid (mRNA) technology-based Monkeypox virus (MPXV) vaccines in combating a lethal Vaccinia virus (VACV) challenge in mice models. Study: Novel mRNA vaccines encoding monkeypox virus M1R and A35R protect mice from a lethal virus challenge. … Read more

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

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In a recent study posted to the bioRxiv* preprint server, researchers designed a coronavirus disease 2019 (COVID-19) vaccine construct using hybrid SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike(S) protein (containing SARS-CoV-2 Delta and Omicron variant mutations) and nucleocapsid (N) protein peptides that confer T lymphocyte-mediated immune protection. Study: De novo design of anti-variant COVID … Read more