Comparison of blood plasma protein expression in mild, moderate, and severe COVID-19 identifies novel disease severity biomarkers

In a recent study posted to the bioRxiv* server, researchers evaluated blood plasma proteins to identify new targets for coronavirus disease 2019 (COVID-19) treatment approaches and prevent complications associated with severe illness. Study: Proteomic profiling identifies biomarkers of COVID-19 severity. Image Credit: Billion Photos/Shutterstock Background There is an unmet need for effective therapies for severe … Read more

Novel prefusion S antigen designed by the mutation of the SARS-CoV-2 Spike protein’s trimeric structure

In a recent study posted to the bioRxiv* server, researchers mutated the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein’s trimeric structure to design a novel prefusion S antigen, S2D14. Study: Structural and Computational Design of a SARS-2 Spike Antigen with Increased Receptor Binding Domain Exposure and Improved Immunogenicity. Image Credit: creativeneko/Shutterstock Background … Read more

Usana acquires revenue outside of Asia with protein bar manufacturer, supplement MLM

Usana, which is based in Salt Lake City, UT, acquired Rise Bar, a manufacturer of protein bars, which is based in Irvine, CA. The manufacturer, which was founded in 2010, bills its products as the ‘simplest’ protein bars. For example, it’s Almond Honey Protein bar features just three ingredients: almonds, honey and whey protein isolate. … Read more

Cryo-electron tomography helps visualize platelet deformation due to SARS-CoV-2 spike protein

In a recent study posted to the bioRxiv* preprint server, researchers used cellular cryo-electron tomography (cryo-ET) to demonstrate the role of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in coronavirus disease 2019 (COVID-19)-triggered severe coagulopathies. Study: Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 Spike protein. Image Credit: Sergejs Pintis/Shutterstock Background … Read more

AI helps design synthetic DNA that controls cells’ protein production

With the help of an AI, researchers at Chalmers University of Technology, Sweden, have succeeded in designing synthetic DNA that controls the cells’ protein production. The technology can contribute to the development and production of vaccines, drugs for severe diseases, as well as alternative food proteins much faster and at significantly lower costs than today. … Read more

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery until now. Researchers of the University of Bristol-led study, published in Science advances today [23 November], say their findings could lead to the development of a pan-coronavirus treatment to defeat all coronaviruses-; from the 2002 SARS-CoV outbreak … Read more

The biological properties of the SARS-CoV-2 E protein in the context of HIV-1

In a recent study published in Retrovirologyresearchers assessed the effectiveness of severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 envelope (E) proteins against human immunodeficiency virus (HIV)-1. Study: The envelope proteins from SARS-CoV-2 and SARS-CoV potently reduce the infectivity of human immunodeficiency virus type 1 (HIV-1). Image Credit: Corona Borealis Studio/Shutterstock Background Viroporins are ion … Read more

Chitin-immobilized nanobodies for SARS-CoV-2 detection

In a recent study posted to bioRxiv*, researchers demonstrated a novel strategy to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using chitin-immobilized nanobodies. Study: Efficient SARS-CoV-2 detection utilizing chitin-immobilized nanobodies synthesized in Ustilago maydis. Image Credit: CROCOTHERY/Shutterstock Background Shark and Camelidae-derived nanobodies are emerging alternatives to traditional antibodies. Nanobodies bind to ligands at the … Read more

SARS-CoV-2 open reading frame 3c protein found to be targeted selectively to mitochondria

In a recent study posted to the bioRxiv* preprint server, researchers presented a functional analysis of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) open reading frame 3c (ORF3c) protein. Study: The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity. Image Credit: Corona Borealis Studio/Shutterstock Background The genome of SARS-CoV-2 encodes a wide … Read more

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

In a recent study posted to the bioRxiv* preprint server, a team of researchers investigated the change in the stability, antigenicity, and protein expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein. Study: Enhanced stability of the … Read more