SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

In a recent study published in the journal PLOS pathogensresearchers investigated the mechanisms through which the human common cold Betacoronavirus OC43 (HCoV-OC43) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit the formation of stress granules. Study: Nsp1 proteins of human coronaviruses HCoV-OC43 and SARS-CoV2 inhibit stress granule formation. Image Credit: MIA Studio/Shutterstock Background Stress … Read more

Cryo-electron microscopy reveals atomic structure of Staphylococcus epidermidis bacteriophage

Cryo-electron microscopy by University of Alabama at Birmingham researchers has exposed the structure of a bacterial virus with unprecedented detail. This is the first structure of a virus able to infect Staphylococcus epidermidis, and high-resolution knowledge of structure is a key link between viral biology and potential therapeutic use of the virus to quell bacterial … Read more

Enjoy holiday treats with moderation in mind

I had the opportunity to take part in a holiday tradition in another state. All the downtown stores with many locally made products stayed open late. They had special sales to launch the holiday season. I was looking forward to the evening. The stores offered treats including cookies, candy, cocoa and apple cider. As fate … Read more

Gut microbial flavonoid catabolite reverses fatty liver disease in mice

In a recent study published in the Proceedings of the National Academy of Sciences (PNAS), Researchers report that a gut microbial catabolite could reduce the cardiometabolic disease (CMD) burden in mice. Study: A gut microbial metabolite of dietary polyphenols reverses obesity-driven hepatic steatosis. Image Credit: SvetaZi / Background Flavonoids exhibit anti-obesogenic, chemoprotective, and antioxidant … Read more

Research suggests a new model of how beige fat biogenesis is controlled

Once considered an inert tissue, fat – or adipose tissue – is now known to play an active role in the body’s critical functions by secreting hormones that regulate hunger and body temperature. Body fat comes in several varieties; for example, white adipose tissue stores excess energy, and brown adipose tissue primarily burns energy. In … Read more

Researchers design a COVID-19 vaccine construct using hybrid SARS-CoV-2 spike protein and nucleocapsid protein peptides

In a recent study posted to the bioRxiv* preprint server, researchers designed a coronavirus disease 2019 (COVID-19) vaccine construct using hybrid SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) spike(S) protein (containing SARS-CoV-2 Delta and Omicron variant mutations) and nucleocapsid (N) protein peptides that confer T lymphocyte-mediated immune protection. Study: De novo design of anti-variant COVID … Read more