The multi-year partnership includes the development of specific proteins using microbial fermentation technology, with the US firm contracting for all phases of product development up until commercial launch. California-based Triplebar Bio Inc. It deploys a proprietary platform, which can analyze animal and microbial cell lines 10,000 times faster than conventional screening methods. The firm uses … Read more
Newswise — scientists from the Federal Research Center “Fundamentals of Biotechnology” of the Russian Academy of Sciences showed that nucleolar protein nucleophosmin (NPM1), the defection of which can cause the development of leukemia and other types of cancer, deals with its regulatory protein only by phosphorylation of nucleophosmin (including “phosphate marker” in its composition). It … Read more
Newswise — an interdisciplinary team of scientists from Cologne, Heidelberg and Munich has discovered a new function of a well-known enzyme: The signal peptidase complex in the endoplasmic reticulum cleaves faulty membrane proteins to initiate their degradation. In our cells, the endoplasmic reticulum is responsible for producing and controlling proteins that get secreted from the … Read more
Newswise — LZTR1 variants take the brakes off oncogenes and could be promising biomarkers for targeted therapies. Investigators at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine, in collaboration with other institutions, have shown that mutated LZTR1 proteins allow EGFR and AXL oncogenes to expand unchecked in cells, leading to … Read more
Newswise — MYC genes and their proteins play a central role in the emergence and development of almost all cancers. They drive the uncontrolled growth and altered metabolism of tumor cells. And they help tumors hide from the immune system. MYC proteins also show an activity that was previously unknown – and which is now … Read more