Using the latest technologies-including both single-nuclear sequencing of mice and human liver tissue and advanced 3D glass imaging of mice to characterize key scar-producing liver cells-researchers have uncovered novel candidate drug targets for non-alcoholic fatty liver disease ( NAFLD). The research was led by investigators at the Icahn School of Medicine at Mount Sinai. Utilizing … Read more
Obesity and metabolic diseases, such as diabetes, are extremely common in the United States. Tiny proteins called microproteins have long been overlooked in research, but new evidence demonstrates that they have an important role in metabolism. Salk scientists have discovered that both brown and white fat is filled with thousands of previously unknown microproteins, and … Read more
Anthracyclines are a class of chemotherapies effective in treating many forms of cancer, including leukemias, lymphomas and breast cancer. Anthracyclines -; such as doxorubicin, frequently used against breast cancer -; kill cancer cells by damaging their DNA. However, these effective chemotherapies also cause toxic heart effects in about ten percent of patients that can eventually … Read more
Newswise — BOSTON Anthracyclines are a class of chemotherapies effective in treating many forms of cancer, including leukemias, lymphomas and breast cancer. Anthracyclines — such as doxorubicin, frequently used against breast cancer — kill cancer cells by damaging their DNA. However, these effective chemotherapies also cause toxic heart effects in about ten percent of patients … Read more
Greek yogurt, due to its high protein content, low-fat and low-sugar properties, is considered best suited for weight management purposes and to build muscle mass as well. Photo: iStock New Delhi: Dahi in its basic form or whipped up to make raita is delicious, for some people a non-negotiable part of meals. While some people … Read more
Altering the diet could be helpful in taking down colon cancer, a new study conducted by researchers from the University of Michigan Rogel Cancer Center reveals, reported by ScienceDaily. unsplash Cancer cells, much like human cells, need nutrients to grow. And one most crucial nutrient-sensing molecule in a cell is dubbed mTORC1. Regarded as the … Read more
Fatty foods harm our health. Prior research has established a link between the consumption of dietary fats and non-alcoholic fatty liver disease, which subsequently leads to inflammation and tumor formation in the liver. However, the precise effects of dietary fat composition on liver tumorigenesis remain elusive. A new study shows that dietary saturated/trans fats, but … Read more
Newswise — scientists from the Federal Research Center “Fundamentals of Biotechnology” of the Russian Academy of Sciences showed that nucleolar protein nucleophosmin (NPM1), the defection of which can cause the development of leukemia and other types of cancer, deals with its regulatory protein only by phosphorylation of nucleophosmin (including “phosphate marker” in its composition). It … Read more
A landmark study by researchers at the Department of Energy’s SLAC National Accelerator Laboratory and Stanford University reveals how a tiny cellular machine called TRiC directs the folding of tubulin, a human protein that is the building block of microtubules that serve as the cell’s scaffolding and transport system . An illustration of a cellular … Read more
Small molecules are a mainstay of drug therapy, many of them work by targeting a protein and blocking it. A newer but still experimental approach leads to the degradation of disease-causing proteins. Research has revealed new insights into the ways proteins can be regulated and Entact Bio is building on that science to expand what … Read more