Novel mRNA-lipid nanoparticle vaccine encoding four mpox virus surface proteins generates robust immune responses against orthopoxviruses

In a recent study posted to the bioRxiv* preprint server, researchers described a messenger ribonucleic acid (mRNA)-lipid nanoparticle mpox vaccine encoding four conserved mpox virus surface proteins which induced mpox virus-specific immunity and elicited heterologous protection when challenged with lethal vaccinia virus. Study: A monkeypox mRNA-lipid nanoparticle vaccine targeting virus binding, entry, and transmission drives … Read more

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

In a recent study posted to bioRxiv*, researchers developed a measles virus (MeV)-vectored vaccine capable of inducing high neutralizing antibody (nAb) responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants. Image Credit: Kateryna … Read more

Study demonstrates robust antibody response elicited by trivalent protein subunit vaccine against SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that a trivalent vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) improved the breadth of humoral immune responses in mice. Study: Trivalent SARS-CoV-2 S1 Subunit Protein Vaccination Induces Broad Humoral Responses in BALB/c Mice. Image Credit: Corona Borealis Studio/Shutterstock Background SARS-CoV-2 vaccines … Read more

The frequency, magnitude, and longevity of natural antibody responses against nine P. vivax vaccine candidate proteins

Malaria is a significant public health threat, causing about 241 million cases worldwide in 2020. Although Plasmodium falciparum is reported to be the most common malaria parasite in Africa, P. vivax is the predominant parasite in most countries in America and Asia Pacific. Critical illnessescaused by P. vivax are no more considered rare events. Study: … Read more

Chitin-immobilized nanobodies for SARS-CoV-2 detection

In a recent study posted to bioRxiv*, researchers demonstrated a novel strategy to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using chitin-immobilized nanobodies. Study: Efficient SARS-CoV-2 detection utilizing chitin-immobilized nanobodies synthesized in Ustilago maydis. Image Credit: CROCOTHERY/Shutterstock Background Shark and Camelidae-derived nanobodies are emerging alternatives to traditional antibodies. Nanobodies bind to ligands at the … Read more

Structure-directed mutagenesis produces thermostable SARS-CoV-2 spike protein trimers with potential vaccine booster applications

In a recent study posted to the bioRxiv* preprint server, a team of researchers investigated the change in the stability, antigenicity, and protein expression of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein trimer using structure-directed mutagenesis to alter a cavity in the core of the spike protein. Study: Enhanced stability of the … Read more

Mosaic nanoparticles displaying spike protein trimers from different coronaviruses elicits cross-reactive protection

In a recent study under review at the Nature Portfolio journal and currently posted to Research Square* preprint server, researchers developed and assessed the immunogenicity of nanoparticles expressing spike trimers from coronaviruses (CoVs). CoVs, particularly beta-CoVs, thrive in animal reservoirs and constantly threaten human health. Seven CoVs infect humans, including severe acute respiratory syndrome coronavirus … Read more

Designing Handling Facilities With Cattle Health in Mind | Dairy News

Having facilities that allow cattle to be worked in a safe, efficient manner provides a wealth of opportunities to improve animal health. Though efficiency is important, focusing on safety is key when designing handling facilities because it will allow you to manage cow health while reducing the risk of injury in both cattle and people. … Read more

New control system could be used to finely tune the production of useful proteins

Using an approach based on CRISPR proteins, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells. This technique could be used to finely tune the production of useful proteins, such as the monoclonal antibodies used to treat cancer and other diseases, or … Read more

SpyCatcher-SpyTag technology used to develop recombinant protein-based intranasal vaccine against SARS-CoV-2

The findings of a new study posted to the bioRxiv* preprint server showed that the intranasal SpyCage vaccine platform can be protective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and may prove to be a versatile and adaptable modality for the formulation of intranasal vaccines that target respiratory pathogens. Study: Intranasal virus-particle mimicking vaccine … Read more