ACE2

Study demonstrates robust antibody response elicited by trivalent protein subunit vaccine against SARS-CoV-2

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In a recent study posted to the bioRxiv* preprint server, researchers demonstrated that a trivalent vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) improved the breadth of humoral immune responses in mice. Study: Trivalent SARS-CoV-2 S1 Subunit Protein Vaccination Induces Broad Humoral Responses in BALB/c Mice. Image Credit: Corona Borealis Studio/Shutterstock Background SARS-CoV-2 vaccines … Read more

SARS-CoV-1 and SARS-CoV-2 spike proteins utilize different mechanisms to bind to ACE2

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A recent study published in the journal Frontiers in Molecular Biosciences applied computational approaches to study the binding mechanisms of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV spike (S) proteins to the human angiotensin-converting enzyme 2 (ACE2) receptor. Study: Spike proteins of SARS-COV and SARS-COV-2 utilize different mechanisms to bind with human … Read more

COVID-19 amplifies damage to the central nervous system in Alzheimer’s disease

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In a recent study published in the journal Annals of Diagnostic Pathologyresearchers Alzheimer in the United States evaluated the impact of coronavirus disease 2019 (COVID-19) on central nervous system (CNS) damage in’s disease (AD). Studies have reported that the human brain is highly susceptible to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated pathological changes. In … Read more

Study indicates that the major determinants of SARS-CoV-2 pathogenicity reside outside of the spike protein

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In a recent study posted to the bioRxiv* server, researchers at Boston University made a chimeric recombinant severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) encoding the spike(S) glycoprotein gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate. Study: Role of spike in the pathogenic and antigenic behavior of SARS-CoV-2 BA.1 Omicron. Image Credit: … Read more